
If you would meet Antonio, the drummer of our band, you would instantly like him. He is one of those people, who makes a friendly remark to people he meets, even if he does not know them. It might be because he was born in a little town in Spain, where everybody knows everybody, everyone is family to everyone, and no one can keep a secret for the neighbors. Antonio is still young, he had his 32nd birthday last July. Five years ago, Antonio was in a bad state. He was having a bad diarrhea, very painful tummy aches, sores in his mouth and he constantly felt like having a bad flu. We, the other band members, started to be worried about his health, because he was losing weight very fast. He used to be a stubby, round square boy, and he turned into a shadow of himself in a couple of months. One night, we were going to play on a local Summerfest in one of the nearby villages, Antonio disappeared during our shared dinner. When he came back, he looked terrible. He did not eat anything, and he had a hard time playing the drums. The next day we pushed him to go and see the doctor, which he finally did. The diagnosis was a surprise to us all: Crones Disease. We had never heard of it, but we would learn fast about the consequences and complications of this seemingly incurable disease.
Crones disease is a chronic inflammatory disease which causes stomach
pains, diarrhea, and weight loss.The disease typically begins between the ages of 20 and
30, and is characterized by periods of activity and
remissions: It often remains quiet and easily controlled for long
periods of time.
The symptoms of Crones disease vary and depend on the severity and location of
the disease, and many patients only have mild symptoms for a long time and have
often had the disease for several years before it is diagnosed.
Common symptoms are:
- Periods of mild fever, sometimes with blood in the stools, and pain in the lower right part of the abdomen.
- Loss of appetite.
- Unintentional weight loss.
- Boils (cavities containing pus) and fistulas (formation of small passages that connect the intestine with other organs or the skin).
- General malaise.
Some problems, outside the bowel, can occur. Arthritis, eye and
skin problems, and - in rare instances - chronic liver conditions
may develop. Bleeding and iron deficiency, reduced bowel mobility, or obstruction (partial or
complete blockage of the intestine), and skin rash. Problems with digestion of food, either due to extensive
scarring in the intestine, or because the intestine has become too short after
a number of operations can also occur. When Crones disease has
been present for many years there is an increased risk of cancer.
The treatment of Crones Disease depends on the severity and extent of the
disease, as well as the effect of the disease on the patient. Medication is used to control the inflammation, keep the
symptoms down, and reduce the probability of relapse. Severe attacks require treatment in hospital. Surgical removal of the affected areas is sometimes necessary,
but it does
not eliminate the disease, and it is not uncommon for people with
Crohn’s Disease to have more than one operation, as inflammation tends
to return to the area next to where the diseased intestine was removed.
Aminosalicylate or corticosteroid enemas
or suppositories are used to reduce inflammation in the acute stage of
mild to moderate attacks of the disease affecting the rectum or lower
part of the intestine. If the disease is higher up in the intestines,
tablets will be used. Severe attacks will lead to admission to hospital and treatment with
intravenous corticosteroids. Furthermore doctors will sometimes use immunosuppressants for very severe symptoms that do not respond sufficiently to
intravenous corticosteroids. Antibiotics will often be given to treat bacterial overgrowth in the small intestine caused by stricture, fistulas, or prior surgery, and medicines against diarrhea will be used if necessary.
It
is clear that all these medicines do have side effects, one more than
the other, and most probable even more so if used over prolonged
periods of time. That medication does not cure the disease, is clear if
we realize that two-thirds to three-quarters of patients with Crohn’s disease will
require surgery at some point in their lives. Surgery is used either
to relieve symptoms that do not respond to medical therapy or to
correct complications such as blockage, perforation, abscess, or
bleeding in the intestine. Surgery to remove part of the intestine can
help people with Crohn’s disease, but it is not a cure. Surgery does
not eliminate the disease, and it is not uncommon for people with
Crohn’s Disease to have more than one operation, as inflammation tends
to return to the area next to where the diseased intestine was removed.
If we have a look at the side effects that the different medicines can have, we encounter the following:
- Diarrhea
- Headache, dizziness
- Increased risk of bleeding in the gastrointestinal tract
- Indigestion, nausea, gas
- Hair loss
- Rash
- Decrease in white blood cells
- High blood pressure
- Mood swings, psychosis, insomnia
- Weight gain, moon facies
- Acne, increased facial hair, stretch marks
- Increased risk of infection
- Osteoporosis
- Headaches
- Vomiting
- Cough
- Sinus infections
- Sore throat

If we make a drawing of the intestines, it would look like this.
(source: www.gicare.com
photo's:http://www.sxc.hu/profile/claudmey ).


